Method for preparing (R)-3-quinuclidinol
2014
The invention provides a method for preparing (R)-3-quinuclidinol. According to the preparation method, an alcohol reacts with 3-quinuclidone under the action of an alkali and a chiral sulfonamide-ruthenium complex, thus preparing the (R)-3-quinuclidinol. The chiral sulfonamide-ruthenium complex serves as a catalyst, and 3-quinuclidone is subjected to asymmetric transfer hydrogenation synthesis to obtain the (R)-3-quinuclidinol. Compared with the prior art, the method provided by the invention is simple,quixk and efficient in preparation process and has extremely high conversion rate, and the product (R)-3-quinuclidinol with high enantio-selectivity and high yield can be obtained and has excellent industrial application prospect.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
0
References
0
Citations
NaN
KQI