Core-Shell Polymer-Based Nanoparticles To Deliver MiR-155-5p To Endothelial Cells

Abstract Heart failure occurs in over 30% of the worldwide population, being most commonly originated from cardiovascular diseases such as myocardial infarction. microRNAs (miRNAs) target and silence specific messenger RNAs thereby regulating gene expression. Since the endogenous miR-155-5p has been ascribed to vasculoprotection, loading it onto positively charged core-shell poly(isobutylcyanoacrylate)-polysaccharide nanoparticles (NPs) was attempted. NPs showed a decrease (p BACH1 was decreased within the cells, being 4-fold down-regulated after 1 day of incubation (p