[The influence of Spirulina and Selen-Spirulina on some indexes of rat's immune status].

: This paper reviews evidence for the immune-enhancing effect of Spirulina (Sp) and Selen-Spirulina (Se-Sp) in male Wistar rats. The rats of control group fed half-synthetic diet. Rats of experimental groups consumed the half-synthetic diets with Sp (10 g/kg diet) or Se-Sp (350 microg Se/kg diet) for 2 weeks. Using rats lymphocytes in vitro after phytohemagglutinin stimulation was demonstrated that lymphocytes from Sp and Se-Sp groups secreted of interleukin-2 and interferon-gamma more control group. Induction of interleukin-4 was comparable with once of control group. We believed that Sp and Se-Sp are more effective in stimulating a Th-1--type response and hence potentiates cell-mediated immunity. The immunostimulatory effect of Sp and Se-Sp was confirmed by morphologic and morphometric investigation of rats spleen, also with by NBT-test of peritoneal macrophages.