Halothane modulates NMDA and non-NMDA excitatory synaptic transmission in rat cortical neurons.

Akira Kitamura,Ryoichi Satoh,Tomoo Nagano,Hiroyuki Matsuda,Toru Shimizu,Atsuhiro Sakamoto,Ryo Ogawa

Halothane modulates NMDA and non-NMDA excitatory synaptic transmission in rat cortical neurons.

2005

Akira Kitamura
Ryoichi Satoh
Tomoo Nagano
Hiroyuki Matsuda
Toru Shimizu
Atsuhiro Sakamoto
Ryo Ogawa

Purpose Although general anesthetics may decrease neuronal excitation, their detailed effects on spontaneous excitatory postsynaptic currents (EPSCs) remain controversial. We investigated and compared the effects of halothane on N-methyl-d-asparate (NMDA) and non-NMDA receptor-mediated postsynaptic currents.

Keywords:

General anesthetics
Anesthesia
Halothane
Neuroscience
Excitatory synaptic transmission
Excitatory postsynaptic potential
Postsynaptic Current
Neuronal excitation
NMDA receptor
Medicine
Patch clamp
Membrane potential
gamma-Aminobutyric acid
Neurotransmission
Glutamate receptor

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