Morphological Transformation by Early Region Human Polyomavirus BK DNA of Human Fibroblasts with Deletions in the Short Arm of One Chromosome 11

Summary Human fibroblasts derived from four individuals with various deletions in the short arm of one chromosome 11 were susceptible to morphological transformation by early region BK virus DNA, whereas diploid human fibroblasts were not. This difference in susceptibility to transformation by early region BK virus DNA might be explained by a putative ‘transformation suppressor’ locus situated within the deleted region on the short arm of chromosome 11.