Abstract 15155: Nonsteroidal Anti-Inflammatory Drug Use in Acute Myopericarditis is Associated With Decreased Late Gadolinium Enhancement at 3 Months Follow-Up

Introduction: Current scientific statements recommend against the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in myocarditis based on animal research. However, the impact of NSAIDs in patients with acute myocarditis has not been studied. Since NSAIDS are standard therapy in pericarditis, we retrospectively investigated their safety in myopericarditis. Methods and results: From September 2010 to May 2017, we identified 61 patients with myopericarditis based on clinical criteria, elevated high-sensitivity troponin T and cardiac magnetic resonance imaging (CMR). Mean age was 41(±17) years, 16% were female. Mean left ventricular ejection fraction (LVEF) was 54% (±10). All patients received standard heart failure therapy. Thirty patients received NSAIDs (Acetylsalicylic Acid: n=8, average daily dose=1300mg or Ibuprofen: n=22, average daily dose=1500mg) for an average duration of four weeks. Three months after diagnosis, 27 patients were re-evaluated by CMR to measure the dynamic of late gadolinium enh...