The Association Between Air Pollution Exposure and Glucose and Lipids Levels.

Context: Evidence from recent decades supports a causal association between air pollution (particulate matter <10 μm in diameter [PM10] and PM <2.5 μm in diameter [PM2.5]) and oxidative stress, possibly involving impaired metabolism of glucose and lipids. Objective: Using a satellite based model to assess PM exposure at 1-km spatial resolution, we examined the associations between PM and glucose, hemoglobin A1c (HbA1c), and lipids. Design: Population-based retrospective cohort study of a 10-year period. Setting: Members of the largest health care provider in Southern Israel. Participants: We included all serum glucose, HbA1c, and lipids tests of subjects with known cardiovascular diseases and risk factors. Subjects' glycemic status was defined as normal or diabetes. Main Outcome: Log-transformed glucose, HbA1c, and lipid values were explored by mixed models, with adjustment for personal and seasonal confounders. Results: We assessed 73 117 subjects with over 600 000 samples. Three-month average concentrat...