Abstract TP343: Low Density Sign in Intracerebral Hemorrhage: A Novel Predictor for Hematoma Expansion

Background: Hematoma expansion in intracerebral haemorrhage (ICH) patients is a major determinant of early deterioration and associated with poor outcomes. Early identification of hematoma expansion with noncontrast computed tomography (NCCT) is very beneficial. We newly identified a NCCT sign called low density sign. Our study was to investigate whether low density sign was applicable for hematoma expansion prediction. Methods: Patients with spontaneous ICH enrolled in Huashan Hospital, Fudan University who underwent baseline NCCT scan within 6 h after ICH onset and the follow-up NCCT scan within 24 h after initial CT scan were included. Hematoma expansion was defined as absolute growth greater than 6 mL or a relative growth of more than 33%. The low density sign was defined as: (1) The hypoattenuation area that easily recognized by the naked eye has an identifiable border and most of the area within the hematoma. (2) The hypoattenuation area may vary in shape and connect or not with the adjacent brain t...