Spontaneous occurrence and chemical induction of neurogenic tumors in rats--influence of host factors and specificity of chemical structure.

From the standpoint of hazard identification of neurooncogenic substances, the specificity of chemical structure for neurooncogenic activity, mode of administration, and influence of host factors such as the strain, sex, and age on the incidence, location, or type of spontaneous or chemically induced rat neurogenic tumors are reviewed and discussed. In addition, diagnostic problems on some of the neurogenic tumors in the practical differential diagnoses are briefly pointed out