Corticosteroid for plasma cell granuloma of the lung

Summary A 69-year-old man presented pleural-based masses and a marked hypergammaglobulinemia. Thoracoscopic lung biopsy revealed the lung pathology as prominent lymphoplasmacytic infiltrates admixed with fibrosis, consistent with plasma cell granuloma (PG). Treatment with corticosteroid (CS) induced complete remission of the lung lesions and normalization of hypergammaglobulinemia. Discontinuation of CS resulted in a resurgence of the lung lesion, which again was remitted on resumption of CS, stressing an efficacy of CS in the condition. This and other published cases affirm the value of treatment with corticosteroids as an acceptable choice for primary and recurrent pulmonary PG.