Synthesis of Quinazolinyl Chalcone Derivatives

quinazolin-ylamino) phenyl-4-(N,N- dimethylamino) phenyl propenyl ketone with total yield of 68.0% was synthesized with 2-aminobenzonitrile and N,N-dimethylformamide dimethyl acetal as a starting material, the synthesis of N-(2-cyanophenyl)-N,N-dimethyl formami- dine, and then amino acetophenone to form a ring, and finally reaction with formaldehyde dimethylaminobenzaldehyde. The experimental conditions were optimized. The results showed that: Intermediate 1 was synthesized by 2-aminobenzon itrile and N, N- dimethylformamide dimethyl acetal and their molar ratio of 1: 2, the optimal reaction temperature is 85 ˚C. Intermediate 2 synthesized optimal temperature of 105 ˚C. Intermediates and target compounds by 1 H NMR, 13 C