Antiproliferative and apoptotic effects of O-Trensox, a new synthetic iron chelator, on differentiated human hepatoma cell lines

We investigated the effects of a new iron chelator, O- increased DNA synthesis and mitotic index in primary cultures Trensox (TRX), compared with desferrioxamine (DFO), of rat hepatocytes stimulated by growth factors (3). Several on proliferation and apoptosis in cultures of the human studies have also shown that iron overload is implicated in hepatoblastoma HepG2 and hepatocarcinoma HBG cell tumor cell growth in vivo (4,5) and the risk of developing an lines. Our results show that TRX decreased DNA synthesis HCC seems to be related to the level and duration of iron