In Vitro DNA and Chromosome Damage Produced by Some Minerals and Man Made Particles on Rat Pleural Mesothelial Cells (RPMC) — Mechanisms and Relationship with in Vivo Experimental Findings

It is now well established that neoplastic transformation results from progressive cell changes involving genes (Boyd and Barrett, 1990); it is then relevant to investigate the effects of particles on the cell structures carrying the genes. Several in vitro assays can be used allowing the detection of effects of potential carcinogens at the DNA and chromosome level. To use these assays as predictive or mechanistic models, one important point is to determine whether differences exist between cell responses to carcinogenic/non carcinogenic particles and why?