A Rare Case of Episodic Angioedema and Hypereosinophilia - Gleich Syndrome

Gleich syndrome is a distinct clinical entity characterized by episodic angioedema, hypereosinophilia and increased body weight. Being a rare cause of hypereosinophilia, extensive diagnostic evaluation has to be carried out to rule out the other common causes like allergic diseases, Idiopathic hypereosinophliic syndrome (HES), connective tissue disorders, parasitic infestations, lympho-proliferative disorders and neoplastic conditions. We report a rare case of Gleich syndrome in a young Indian female. It usually runs a benign course and shows a good response to low dose corticosteroid therapy.