STUDIES ON THE CONVULSIVE REFLEX PRODUCED BY STRYCHNINE. II. AS MODIFIED BY EPINEPHRINE

1. Epinephrine is antagonistic to the paralytic action of strong strychnine solutions on the heart. 2. Epinephrine and strychnine have a synergistic action on the cord. Spasms develop more quickly when epinephrine is given with or previous to strychnine. 3. Strychnine is antagonistic to the general depression produced by epinephrine, but this antagonism is not mutual. Epinephrine will not antagonize a strychnine spasm. 4. From the above findings there is no indication that epinephrine can be applied with benefit in the treatment of strychnine convulsions.