Efficacy of yttrium-90 (Y90) radioembolization in patients with chemorefractory colorectal cancer (CRC) liver metastasis: Results of Bologna study.

e14547 Background: Y90 radioembolisation is a promising treatment for chemorefractory CRC liver metastasis patients (pts). This pilot study investigated in a single institution the safety/efficacy of the Y90 therapy. Methods: We enrolled consecutive pts referred to S.Orsola-Malpighi Hospital, Bologna, whose CRC liver metastasis had progressed to ≥2 CT lines was enrolled. Eligible pts had: adequate hepatic function, absence of mayor hepatic vascular anomalies, only liver metastasis or liver metastasis with limited extra-hepatic disease. Safety was assessed according to CTC-NCI 3.0 at 1 week and monthly thereafter for 6 months post-therapy. Efficacy was assessed by CT at 1, 3 and 6 months. PFS/OS analysis was performed using the Kaplan-Meier estimation. Predictive factors were tested using Cox analysis. Results: Between January 2006-April 2013, 56 pts were enrolled and underwent Y90 therapy. Pt characteristics were: 43(76.8%)M, 13(23.2%)F; median age 64(42-82) y; ECOG PS-0 49(87.5%), PS-1 7(12.5%); previous...