Safety and efficacy of intrathecal drug delivery for pain

SUMMARY The practice of delivering analgesic drugs into the intrathecal space has evolved over the past several decades from a ‘last-ditch’ therapy for intractable pain in patients with terminal cancer to a more widely applied strategy for treating patients with chronic nonmalignant pain as well. This review discusses the available safety and efficacy data of intrathecal drug delivery with a focus on device- and user-related safety issues.