Development of diagnosis

: Kawasaki disease (KD) is an acute vasculitis that affects most often in children. This is unknown etiology of KD. Therefore, KD is diagnosed by characteristic symptoms. The standard care of acute KD is high-dose intravenous immunoglobulin(IVIG) treatment and aspirin. IVIG has been observed to reduce both the duration of fever and the incidence of coronary artery aneurysms when given within a few days of the onset KD. However, despite receiving IVIG within the first 10 days of illness, 10-20% of patients are resistant to initial IVIG treatment. And approximately 5% of children with KD have subsequent coronary aneurysms. Recently, it became the problems that adequately diagnose KD and early deject resistant initial IVIG case.