Pyrrolo [2,3-b] pyridines and pyrrolo [2,3-b] heteroaryl substituted pyrimidines as inhibitors of Janus kinases

A pharmaceutical composition comprising a compound of Formula: ** Formula ** or delamisma pharmaceutically acceptable salt, wherein: 2 T, U and V are independently selected from O, S, N, CR5 and NR6; 0 wherein the ring members consisting of a carbon atom, a nitrogen atom, U, T and V is aromatic; X is N or CR4; n is 0; n is I and Y is C 1-8 alkylene, alkenylene C2-8, (CR11R12) pC (O) (CR11R12) q, (CR11R12) pC (O) NR (CR11R122) q, (CR11R12) pC (O) O ( CR11R12) q (CR11R12) pOC (O) (CR11R12) q, wherein said C 1-8 alkylene or alkenylene C2-8, optionally substituted with 1, 2 or 3 halo, OH, CN, amino, C1-4alkylamino or dialkylamino C2-8; Z is aryl, cycloalkyl, heteroaryl or heterocycloalkyl, each opcionalmentesustituido with 1, 2, 3, 4, 5 or 6 substituents independently selected from halo, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl , C1-4 hydroxyalkyl, cyanoalkyl 1-4, Cy1, CN, NO2, ORa, SRa, C (O) kb, C (O) NRcRd, C (O) OR 3 a, 0 OC (O) Rb, OC (O ) NRcRd, NRcRd, NR c C (O) R b, NR c C (O) NR c R d, NR c C (O) OR, S (O) Rb, S (O) NR c R d, S (O) 2 R b NRCS (O) 2 R b, and S (O ) 2NRcRd; Cy1 is independently, each optionally substituted with 1, 2, 3,4 or 5 substituents independently selected from halo selected from aryl, heteroaryl, cycloalkyl and heterocycloalkyl, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1 -4, CN, NO2, ORa ', SRa' ', C (O) Rb' ', C (O) NRc''R3 d' ', C (O) OR', OC (O) Rb '' , OC (O) NRc''Rd '' NRc''Rd '' NRc''C (O) Rb '', NRc''C (O) OR ''S (O) Rb' ', S ( O) NRc''Rd '', S (O) 2 R b '' and S (O) 2NRc''Rd ''; R4 is H; R5 is H, halo, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, CN, NO2, OR7, SR7, C (O) R8, C (O) NR9R10, C (O) OR7, OC (O) R8, OC (O) NR9R10, NR9R10, NR 9 C (O) R 8, NR 9 C (O) OR7, S (O) R8, S (O) NR9R10 40 S (O) 2R8, NR 9 S (O) 2R8 or S (O) 2NRR10; R6 is H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 haloalkyl, OR7, C (O) R8, C (O) NR9R10, C (O) OR7, S (O) R8, S (O) NR9R10, S (O) 2R8 or S (O) 2NR9R10; R7 is H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, alquiniloC2-6, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl; R8 is H, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl; R9 and R10 are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkylcarbonyl, arylcarbonyl, alquilsulfoni the C1-6, arylsulfonyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl and heterocycloalkylalkyl; or R9 and R10 together with the N atom to which they are attached form a group 4, 5, 6 or 7 members; R11 and R12 are independently selected from H, halo, OH, CN, C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 hydroxyalkyl, cyanoalkyl C1-4, aryl, heteroaryl, cycloalkyl and heterocycloalkyl; Ra and Ra '' are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6alkenyl, C2- 6, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl and heterocycloalkylalkyl, wherein said C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2 or 3 substituents independently selected from OH , CN, amino, halo, C1-6 alkyl, haloalkyl C1-66, aryl, arylalkyl, heteroaryl, 0 heteroarylalkyl, cycloalkyl and heterocycloalkyl; Rb and Rb 'are independently selected from H, C1-6 alkyl, C1-6 haloalkyl, C2-6alkenyl, C2- 6, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl and heterocycloalkylalkyl, wherein said C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, 6 cycloalkyl, heteroaryl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2 or 3 substituents independently selected from OH, CN, amino, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl; Rc and Rd are independently selected from H, C1-10 alkyl, C1-6 haloalkyl, C2-6alkenyl, C2- 6, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl and heterocycloalkylalkyl, wherein said alkyl C1-10, C1-6 haloalkyl, C2-5 alkenyl 6, C2-6alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2 or 3 substituents independently selected from OH, CN, amino, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl or heterocycloalkyl; or Rc and Rd together with the N atom to which they are attached form a group 4, 5, 6 or 7 membered optionally substituted with 1, 2 or 3 substituents independently selected from OH, CN, amino, halo, C1 alkyl 6, C1-6 haloalkyl, C1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl; Rc 'and Rd' 'are independently selected from H, C1-10 alkyl, halo C1-6, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl and heterocycloalkylalkyl, wherein said C1-10 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, arylalkyl, heteroarylalkyl, cycloalkylalkyl or heterocycloalkylalkyl is optionally substituted with 1, 2 or 3 substituents independently selected from OH, CN, amino, halo, C1-6 alkyl, C1-6 haloalkyl, C1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl; or Rc 'and Rd' together with the N atom to which they are attached form a group 4, 5, 6 or 7 membered optionally substituted with 1, 2 or 3 substituents independently selected from OH, CN, amino, halo , C1-6 alkyl, C1-6 haloalkyl, C1-6 haloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl and heterocycloalkyl; p is 0, 1, 2, 3, 4, 5 or 6; q is 0, 1, 2, 3, 4, 5 or 6 and a pharmaceutically acceptable carrier; wherein said composition is suitable for oral administration and to provide sustained release of said compound or said salt.