Study on the Fe3O4@Fructus mori L. polysaccharide particle with enhanced antioxidant activity and Bioavailability

The molecular conformation was closely related to the functional properties of macromolecules. To further prove the bioactivity of mulberry fruit polysaccharides (MFP) was greatly affected by its conformation and improve adsorption property, we have designed Fe3O4@MFPNPs core-shell nanoparticles. The spherical Fe3O4@MFPNPs have been successfully synthesized with particle size distribution in the range of 3-10 nm and 68-164 nm, which were smaller than their original polysaccharides and MFP-Fe(III) prepared before. By comparision, the Fe3O4@MFPNPs showed better antioxidant activity than that of MFP and MFP-Fe(III). The different antioxidant activity between Fe3O4@MFPNPs and MFP-Fe(III) that both were modified based on element iron may be contributed to their different conformation that the MFP-Fe(III) were rod-shaped while Fe3O4@MFPNPs were spherical. Furthermore, the Fe3O4@MFPNPs also exhibited higher absorption in small intestine, which will promote its function exertion in human health.