Renal survival in membranoproliferative glomerulonephritis (MPGN): Role of long-term treatment with non-steroid anti-inflammatory drugs (NSAID)

The renal survival of 53 MPGN patients treated on a long-term basis by nonsteroid anti-inflammatory drugs (NSAID) was compared to that of untreated MPGN patients previously reported in the literature. The difference between NSAID-treated and untreated patients (Habib's and Legrain's series) was significant by chi-square and logrank test performed during 10 and 14 years of follow-up. Our results were not significantly different from those observed by West in 45 MPGN children treated by steroids alone or in association with cytotoxic agents. After a follow-up of 14 years, 21 among our NSAID patients were in renal survival and 8 in end-stage renal disease (ESRD). They were respectively 11 and 3 in West' series, and for the untreated groups, 4 and 19 in Legrain's series and 1 and 33 in Habib's series.