Discovery of a Special Intramolecular Aldol-Like Reaction in the Synthesis of Related Substance E of Tadalafil

* E-mail: xiaobei@ecust.edu.cn, zhangshilei@suda.edu.cn Received February 26, 2016; revised April 12, 2016; published online April 20, 2016. Project supported by the National Natural Science Foundation of China (Grant No.21202112), Ph.D. Programs Foundation of Ministry of Education of China (No. 20123201120019) and PAPD (A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions). 国家自然科学基金(No. 21202112)、教育部博士点基金新教师类项目(20123201120019)、江苏高校优势学科建设工程资助项目.