Meta-analysisofAll-CauseMortalityAccordingtoSerum 25-HydroxyvitaminD

We examined the relationship between serum 25hydroxyvitaminD(25[OH]D) and all-cause mortality. We searched biomedical databases for articles that assessed 2 or more categories of 25(OH)D from January 1, 1966, to January 15, 2013. We identified 32 studies and pooledthedata. The hazard ratio for allcause mortality comparing the lowest (0‐9 nanograms per milliliter [ng/mL]) to the highest (>30 ng/mL) category of 25(OH)D was 1.9 (95% confidence interval= 1.6, 2.2; P<.001). Serum 25 (OH)D concentrations less than or equal to 30 ng/mL were associated with higher all-causemortality thanconcentrations greater than 30 ng/mL(P<.01). Our findings agree with a National Academy of Sciences report, except the cutoff point for all-cause mortality reduction in this analysis was greater than 30 ng/mL rather than greater than 20 ng/mL. (Am J Public Health. 2014;104:e43‐e50. doi:10.