Abstract A22: Single institution analysis of disparities in colon rectal cancer in Hispanics and non-Hispanics.

Purpose: Despite advances in treatment and decreasing mortality rates in colorectal cancer over the past decade, Hispanics have experienced less improvement in mortality rates compared to other racial groups. We investigate whether delays in presentation and treatment contribute to less improvement in Hispanic. Methods: Our study is a retrospective cohort study on 158 patients treated for stage IV colorectal cancer presenting from 2006-2011 to Los Angeles County (LAC-USC) Medical Center. All patients had at least one cycle of their first line chemotherapy completed at LAC- USC. We assessed potential factors such as time from symptom to presentation, time from presentation to treatment, age, gender, race, tumor site, and stage at time of diagnosis. Statistical analysis used the aforementioned data as covariates comparing Hispanics to non-Hispanic whites and analyzed by the Cox proportional hazard model. Result: Median age 54 (21-82) years old, 58% of patients were male and 42% were female. 54% of patients were Hispanics, 25% were Asian, 11% were Black and 10% were White. 69 % of patients had metastatic disease at the time of diagnosis and 31% had non-metastatic disease. 47% of patients had left sided cancer, 25% had right sided and 28% had rectal cancer. Median time between symptom to presentation was 83 days; 88 days in Hispanics, 86 days in non-Hispanic Whites (NHW), 93 days in Blacks and 81 days in Asian. Median start day of treatment was 88 days; 103 days in Hispanics, 116 days in NHW, 31 days in Blacks and 66 days in Asians. Median age at the time of presentation, location of tumor, time between first symptom to presentation and time between presentation and treatment were not significantly significant in Hispanics compared to NHW. Conclusions: In our small cohort we failed to show any association between race, presentation, and initiation of treatment. This data suggests that biological differences in Hispanics may be contribute to colorectal outcomes. Note: This abstract was not presented at the conference. Citation Format: Steven Yu, Maryam Shabihkhani, Dongyun Yang, Afsaneh Barzi. Single institution analysis of disparities in colon rectal cancer in Hispanics and non-Hispanics. [abstract]. In: Proceedings of the Fifth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2012 Oct 27-30; San Diego, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2012;21(10 Suppl):Abstract nr A22.