DISTRIBUTION OF POLYMORPHIC VARIANTS OF GENES SYSTEM HEMOSTASIS AND FOLATE METABOLISM CHILDREN IN THE ACUTE GLOMERULONEPHRITIS

PURPOSE OF THE RESEARCH: to study the prevalence of prothrombotic polymorphisms of the hemostatic system in children with acute glomerulonephritis. PATIENTS AND METHODS: analysis of carriers of prothrombotic polymorphisms in acute glomerulonephritis in children. Genes are candidates for predisposition to increased thrombus formation was investigated by PCR the allelic variants of genes of factors II prothrombin (G20210А); factor V Leiden (G1691A), factor VII clotting (G10976A); factor XIII of blood coagulation (G226A); fibrinogen G(-455)A; inhibitor of plasminogen activator PAI-1 4G(-675)5G; and polymorphic gene variants of folate cycle disorders: methylenetetrahydrofolate reductase – (MTHFR C677T, MTHFR А1298С), B12-dependent methionine synthase (MTR А2756G) and methionine synthase reductase – (MTRR A66G), 31 children: 20 children with endocrine nephrotic syndrome; 11 children with acute glomerulonephritis nephritic syndrome. RESULTS: it was found that the frequency of the major allele 5G (-675) of the gene PAI-1 50% statistically significantly (p=0,042) above was determined in children with endocrine NS group than in healthy children. When comparing the distribution of allele frequencies, genotypes of the genes of the hemostatic system and folate metabolism in patients with acute GN nephritic syndrome and the control group, statistically significant differences were revealed. In the study found that in children with acute glomerulonephritis often have a combination of prothrombotic polymorphisms – 48,4% (p<0.05), dominated by compounds of the genotype 677 CT MTHFR gene and genotype (-675) 4G5G PAI-1 gene in 40% of children. Coagulation status associated with dysfunction of hemostasis is more pronounced in the combination of acute glomerulonephritis and gene-genych Association of prothrombotic polymorphisms than in the control group. CONCLUSION: the Heterozygous genotype 677 CT MTHFR gene is 60% and the heterozygous genotype AD 66 gene MTRR 70% occur with greater frequency than in the control group.