Rare Combination of Gelastic Epilepsy, Agenesis of the Corpus Callosum, and Hamartoma

Abstract Gelastic seizures are rare and are associated with different conditions, but mainly with hypothalamic hamartoma. We report on a boy who presented with mental retardation, aggressive behavior, and generalized tonic-clonic and gelastic seizures. Cranial imaging studies revealed a very rare combination of hypothalamic hamartoma and agenesis of the corpus callosum, which was only reported once previously. His seizure activities demonstrated a modest response to anticonvulsants.