Preoperative External Beam APBI: Report of Acute Toxicities From 2 Prospective Clinical Trials Using Two Different Fractionation Schemes

treatments. Patients then received salvage hyperthermia, weekly or twice weekly, with radiation (median 35.5 Gy). Results: Twenty-six (87%) patients received prior radiation therapy (median 60.4 Gy). Median follow-up was 7.7 months. Complete response (CR) was observed in 15 patients (50%), partial response (PR) in 4 patients (13%), and stable disease (SD) in 11 patients (37%). Twenty-two patients experienced acute grade 1 and 2 toxicities, primarily pain and erythema, and twenty-two experienced long-term grade 1 and 2 toxicities, mainly lymphedema and hyperpigmentation. Conclusion: Hyperthermia and radiation provide good local control with a favorable side effect profile in heavily pretreated patients. Thermoradiation therapy should be considered for patients with locally recurrent breast cancer. Author Disclosure: J.S. Yu: None. S. Dharmaiah: None. V. Rao: None. A.R. Godley: None.