Factors predicting the outcome in febrile neutropenia: A study from a tertiary cancer center in India.

e20684 Background: Febrile neutropenia (FN) is common in patients undergoing chemotherapy. The risk dramatically increases in those with absolute neutrophil count (ANC) less than 100/ mm3. Methods: In this 2 year studyall FN patients admitted at our center between January 2011 and November 2012 were analyzed for clinical profile, microbiologic isolates, mortality and factors affecting outcome. IBM statistic SPSS version 19 was used to analyze the data. Results: There were 333 episodes of FN during the study period. Majority (89.7%) of FN episodes occurred in patients with hematologic malignancies and 87% of episodes had ANC< 500. Induction, consolidation and maintenance related episodes were 125 (37.5%), 125 (37.5%) and 17 (5.1%) respectively. First line antibiotics (cefipime, Cefaperazone- Sulbactum + aminoglycoside), second line antibiotics (carbapenam) and antifungals were used in 44.4%, 15.6 % and 34% episodes respectively. Gram negative organisms accounted for 51.6% of the isolates. Prognostic signif...