Study of XAILIN HA Physical Properties versus Marketed Hyaluronate Based Ocular Lubricants

Purpose Xailin HA is a multi-dose lubricating eye drop for alleviating symptoms of moderate to severe dry eye sensations. It contains sodium hyaluronate (HA) 0.2% w/w and sodium perborate in aqueous buffered vehicle. Perborate is a disappearing preservative that turns into water and oxygen upon contact with the ocular surface. Comparative studies were performed with Xailin HA against other EU marketed HA products in order to assess its key physical properties. Methods The parameters studied were the following: Macroscopic appearance, pH, osmolality, viscosity at 25°C, drop size and surface tension. The marketed products assessed in this study were: Xailin HA, Vismed multi, Hyabak, Hyalistil, Optive Fusion, Hylo-Comod, Hylo-vision HD, Artelac Splash MDO, Hylo-Gel. Results All products are clear and colourless and their pH range is between 6.8 and 7.4. The tested products remain in the common range of osmolality for topical ophthalmic forms except Vismed multi (hypotonic, 150 mOsm/kg). Xailin HA presents the next lower osmolality (260 mOsm/kg). Four categories from less to more viscous products are observed: (i) Hyabak and Hylo-Vision (ii) Artelac Splash MDO, Hyalistil, Optive Fusion, Hylo-Comod and Vismed Multi (iii) Xailin HA (iv) Hylo-Gel Xailin HA is significantly different from all others products with the lowest surface tension recorded. Conclusions Xailin HA is a new hyaluronan-based ocular lubricant. Its low surface tension property should reflect a better distribution and spreading capacity on corneal surface than the other marketed products tested.