A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages

Haihui Lu,Karl R. Clauser,Wai Leong Tam,Julia Fröse,Xin Ye,Elinor Ng-Eaton,Ferenc Reinhardt,Vera S. Donnenberg,Rohit Bhargava,Steven A. Carr,Robert A. Weinberg

A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages

2014

Haihui Lu
Karl R. Clauser
Wai Leong Tam
Julia Fröse
Xin Ye
Elinor Ng-Eaton
Ferenc Reinhardt
Vera S. Donnenberg
Rohit Bhargava
Steven A. Carr
Robert A. Weinberg

Weinberg and colleagues report that monocytes and macrophages interact with stem-like human mammary epithelial cells to create a breast cancer stem cell niche.

Keywords:

Breast cancer
Cell biology
Cell growth
Juxtacrine signalling
Epithelial–mesenchymal transition
Stem cell niche
Signal transduction
Cancer stem cell
NFKB1
Biology
Niche
breast cancer stem cell

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