UJI EFEK HIPOGLIKEMIK KOMBINASI EKSTRAK ETANOL DAUN SAMBILOTO (Andrographis paniculata Nees) dengan AKARBOSE pada TIKUS PUTIH (Rattus norvegicus) TERINDUKSI ALOKSAN

Acarbose and sambiloto have the same mechanism of action in lowering blood glucose levels by inhibiting alfaglukosidase enzymes in the gut. This study aims to determine the hypoglycemic effect and combination effect from ethanol extract of  sambiloto leaves ( Andrographis paniculata Nees) with acarbose in rat ( Rattus norvegicus ) induced alloxan. Twelve Wistar rats were divided into 4 groups; negative control, positive control, and two treatment groups (EEDS 59 mg/kgBW with Acarbose 2,05 mg/kgBB as combination I and  EEDS 234 mg/kgBW with Acarbose 2,05 mg/kgBB as combination II). Diabetes Mellitus  was induced by Aloksan Monohidrate dose 135 mg/kg BB  for three days. Level of blood glucose was measured with glukometer at 2, 4, 6 and 8 day.  Treatment with combinations of EEDS doses 59 and 234 mg/kgBW  and Acarbose 2,05 mg/kgBB for 7 days significantly decreased blood glucose  level (p<0,05) by 48,97 %, and 58,81 %  respectively. Keyword : Hypoglycemic; Andrographis paniculata Nees.; Blood glucose level; Acarbose; Combination