The Effect of 2-Thiophenecarboxylic Acid on Growth Plate in the HEBP Induced Rachitic Rats

2-Thiophenecarboxylic acid, a hypoglycemic and antilipolitic agent first described by Fang, was subsequently shown to produce hypocalcemic and hypophosphatemic effects in rats. The hypocalcemic effect of 2-TCA is very similar to that observed after treatment of rats with calcitonin.We reported previously that calcitonin enhanced calcification in growth plate of rat in HEBP induced rickets.In attempt to clarify, the effects of 2-TCA on the growth plate in HEBP induced rachitic rats were studied. 2-TCA promoted the calcification in growth plate, which was found on the soft X-ray photos and contact microradiogram. Measuring the mineral content of growth plate with a microdensitometer, ΣGS/D of HEBP treated group was 194μ Aluminium, that of HEBP+2-TCA treated group was 254μ Aluminium. The mode of promotive action of calcification with 2-TCA in the growth cartilage in HEBP induced rachitic rats was similar to that of the calcitonin.