INCREASING CYCLOPHOSPHAMIDE ANTITUMOR ACTIVITY BY COMBINATION OF LYSOZYME AND LACTULOSE. EXPERIMENTAL EVALUATION

Institute of Baby Feeding, Russian Academy of Agricultural Sciences, MoscowABSTRACTAntitumor activity of cyclophosphamide (NY) increases with combined long-term oral introduction of lactulose(LACT) and hen white egg lysozyme (HWEL). This phenomenon in semisyngeneic system was stronger than the effectof CY+HWELin F1 hybrid mice with intraperitoneally transplanted EL4 lymphoma. The LACT alone did influence nei-ther rate of growing lymphoma, nor CY antitumor activity. CY+HWEL+LACT inhibited the increasing of ascites inmice and the tumor cells dissemination. In contrast to untreated or with CY-treated mice adoptive transfer of the spleencells from the donors treated with CY+HWEL or CY+HWEL+LACT was accompanied by high level of growth inhibi-tion in EL4 recipients. In comparison with the untreated or treated with CY mice there was the normalization of the dif-ferent host parameters, including heart, a wall of intestines, lung or lymphoid organs, levels bifidobacteria or lactobacil-li in contents of a large intestine after introduction of CY+HWEL+LACT. The received data indicate that the combina-tion HWEL+LACT can appear useful as treatment of cancer patients.Key words:antitumor action, cyclophosphamide, lysozyme, lactulose, experiment.