Determination of human absorbed dose from [153Sm]-Samarium maltolate based on distribution data in rats

Background: Therapeuc radiopharmaceucals are designed to deliver high doses of radiaon to selected target organs with an aim of minimizing unwanted radiaon to surrounding healthyssue. Due to the potenal of targeted radiotherapy to treat a wide range of malignant condions, ( 153 Sm)-samarium maltolate was developed for possible therapeuc applicaons. Materials and Methods: The organ radiaon-absorbed doses have been evaluated for human based on animal data. A%er intravenous administraon of 153 Sm-Mal to four groups of rats, they were sacrif iced at