P2-141Association between QoL and Gastrointestinal Chemotherapy Toxicity in Breast Cancer Patient: A Preliminary study

Abstract Background Chemotherapy, which still is the first line for Breast Cancer treatment, plays a significant role in the undesirable side effects including Gastrointestinal Chemotherapy Toxicity, such as Nausea, Vomiting. Even though there are a lot of studies which show adequate Quality of Life (QoL), minimum data is reported in Indonesia on breast cancer patients. The purpose of this study is to assess the QoL in the breast cancer patient in Indonesia influenced by GI chemotherapy toxicity. Method A cross-sectional study was done at the general hospital in Tangerang, Indonesia from October 2018- February 2019. The breast cancer patient who has underwent adjuvant chemotherapy is included in this study and assessed using BR23 questionnaire which assess the functional and symptoms scale of the patient, ranged from 0% (worst function and most symptoms) to 100% (the best function and no symptoms) and National Cancer Institute Common Toxicity Criteria (> 1 consider as toxic). Association between both variables are analysed with Spearmans correlation using SPSS version 24.0 Result The data was collected from 32 patients with mean age of 47.72 ±9.095. It is found that functional scale mean is 55.47% ± 8.53 and toxicity scale mean is 85.89% ±11.61. 30 patients has experienced no chemotherapy toxicity. The association between Functional QoL and Gastrointestinal Chemotherapy Toxicity is defined as 0.254 with the p-value of 0.161, while the association between Symptoms QoL and Gastrointestinal Chemotherapy Toxicity is defined as - 0.308 with the p-value of 0.08. Conclusion Majority of the patients shows adequate Quality of Life and no experienced any chemotherapy toxicity. the association between QoL and Gastrointestinal Chemotherapy Toxicity is low. Thus, further investigation with greater number of sample is needed to confirm the result.