Research progress of acute kidney injury biomarkers

Incidence of acute kidney injury (AKI) is increasing rapidly to epidemic proportions. Development of AKI is associated with increased morbidity, mortality and hospitalization costs. Currently available diagnostic tools are mostly insensitive for early diagnosis of AKI. Finding an early, reliable, easily reproducible, economical and accurate biomarker for AKI is a top research priority. In recent years, many serum and urinary proteins have been investigated as possible early markers of AKI.（Chin J Lab Med,2014,37:425-429） Key words: Acute kidney injury; Biological markers; Creatinine; Cystatin C