Cytotoxic effect induced apoptosis in lung cancer cell line on Ageratina adenophora leaf extract

Abstract Ageratina, adenophora, (A. adenophora) is a conventional prescription plant utilized for various purposes in around the world. However, its biological impacts and their potential components have not been adequately examined. The present investigation assessed the anticancerous properties of A. adenophora leaf extract. The methanolic extract inspired the most pronounced cytotoxic effect in lung cancer cells (A549), as appraised by MTT assay performed 24 h after treatment, demonstrating an IC50 estimation of 50.08 ± 0.14 of low concentration in 40μg/mL. The anti-proliferative movement watched following A. adenophora treatment was related to morphological (Giemsa staining) and nuclear (Propidium Iodide staining) changes of apoptosis. The outcomes propose that A. adenophora could present as a potential wellspring of alternative medication drugs for treating cancer. Further research is required to find out the effective mechanisms responsible for anticancer properties.