Synthesis of 5,7-diarylpyrazolo[1,5-a]pyrimidines via KOH mediated tandem reaction of 1H-pyrazol-3-amines and chalcones
2015
Abstract An efficient and facile protocol has been developed for the synthesis of pyrazolo[1,5- a ]pyrimidines through the tandem reaction of 3-aminopyrazoles and chalcones in the presence of catalytic amounts of KOH. The reported method offers access to 5,7-diarylpyrazolo[1,5- a ]pyrimidines in good to excellent yields. A gram-scale reaction has been performed to demonstrate the potency of optimized procedure for the scale-up processes.
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