CT perfusion in assessment on radiation effect of rabbit VX2 enterocoelia implanted tumor

Objective To explore the application value of CT perfusion in assessment on radiotherapy effect of rabbit VX2 enterocoelia implanted tumor.Methods VX2 enterocoelia implanted tumor rabbit models were built,and then were divided into treated group and control group randomly.The rabbits in treated group were treated with radiotherapy,yet rabbits in control group were only fed.Rabbits in two groups underwent CT perfusion(CTP) before and one week after radiotherapy or feeding.The first and the second CTP parameters(blood flow ,blood volume and permeability surface ) were compared between treated group and control group.Then,the correlation of tumor size,CTP parameters and MVD in two groups were analyzed.Results There were 10 experimental rabbits in the treated group and control group,respectively.One week after radiotherapy,BF,BV and PS of the VX2 tumors in treated group noticeably decreased compared to before radiotherapy(all P0.01),which were obviously lower than those in control group(all P0.01).There was no statistical different in BF,BV and PS of control group between the two times.MVD in the two groups were statistical different(t=12.67,P0.01).In solid area of tumor,BF and BV were positively correlated with MVD(r=0.72,0.63,both P0.05),but PS was not correlated with MVD(r=0.40,P0.05).Conclusion CTP can be used to evaluate radiotherapy effect of rabbit VX2 enterocoelia implanted tumor.