Risk factors for pancreatic cancer in Wenzhou area

Objective To investigate the risk factors of pancreatic cancer in Wenzhou area. Methods A case control study was conducted on 220 cases with pancreatic cancer and 220 matched controls using conditional logistic regression analysis. Results Univariate analysis showed BMI>30 kg/m2, smoking, reproductive history, diabetes, cholecystitis, chronic pancreatitis, history of appendectomy, history of partial gastrectomy, history of cancer and familial history of cancer were associated with pancreatic cancer, while multivariate conditional logistic regression analysis showed that the risk factors of pancreatic cancer included smoking (OR=3.624, 95%CI 1.474~8.907), BMI>30 kg/m2 (OR=1.789, 95%CI 1.030~3.108), diabetes (OR=3.191, 95%CI 1.094~9.309), chronic pancreatitis (OR=4.972, 95%CI 1.593~14.898), and cholecystitis (OR=2.289, 95%CI 1.024~5.116). Conclusions BMI>30 kg/m2, smoking and diabetes are risk factors for pancreatic cancer in Wenzhou area. Key words: Pancreatic neoplasm; Regression analysis; Risk factors; Logistic models