Applying Novel Body-Worn Sensors to Measure Stress: Does Stress Affect Wound Healing Rates in the Diabetic Foot?

Background and Aim: In the United States alone, diabetic limb complications and amputations are estimated to cost $17 billion. Significant risk factors that may lead to amputation of the diabetic foot include ineffective wound healing and infection of a wound or ulcer. Previous studies have shown that wound healing is slowed and patient's susceptibility to infection is increased when a patient is under chronic stress. To date, objective measures of stress have not been used to determine if stress affects the rate at which wounds heal. Our study used novel real-time monitoring of patient's heart rate variability to objectively determine the stress levels of patients visiting a surgery clinic for wound dressing changes. The wound healing rates of patients with high stress levels were compared to healing rates of low-stress individuals to assess the effect of stress on rates of wound healing among diabetics with a history of foot ulceration. Methods: Twenty patients (age: 56.7 ±  12.2 years) with diabetic fo...