FRI0083 Reduced increase of ACPA IGG-FC galactosylation during pregnancy in comparison to total IGG: an explanation why autoantibody positive RA-patients improve less during pregnancy?

BackgroundRheumatoid arthritis (RA) disease activity (DAS28-CRP) improves less during pregnancy in autoantibody positive patients.1 The most specific autoantibodies for RA are anti-citrullinated protein antibodies (ACPAs), which mainly occur as the immunoglobulin (Ig) G isotype. An association with