Synthesis of some new quinazolin-4(3H)-one derivatives and evaluation of their anticonvulsant activity

We reported the synthesis of a novel series of quinazolin-4(3H)-one derivatives bearing oxadiazole, thiadiazole, and other moieties in the 3-position of the quinazolinone nucleus using appropriate synthetic route. The compounds were evaluated for their anticonvulsant activity using picrotoxin model, GABA-A receptor antag- onist. Five compounds showed significantly prolonged times for convulsions compared with the standard drug phenobarbital. Graphical abstract