Studies on the Mechanism of Action of Secretin on Gastric Secretion

Summary Intravenously administered secretin (Boots) caused profound inhibition of food-induced secretion of gastric acid from Heidenhain fundic pouches in 10 dogs. Diversion of bile from the duodenum by means of an external (seven animals) or internal (three animals) biliary fistula abolished the inhibitory effect of secretin upon food-induced secretion from the Heidenhain pouches. The instillation of bile into the duodenum alone or during the intravenous administration of secretin caused inhibition of food-induced secretion, although the duodenal instillation of sodium taurocholate failed to reproduce the effect of whole bile. Secretin inhibited food-induced secretion from the Heidenhain pouches in three dogs with complete ligation of the pancreatic ducts.