In situ X-ray diffraction study of the processes that occur upon annealing frozen solutions in systems with clathrate formation, aimed at developing new forms of medicinal substances with improved properties

The use of in situ powder diffraction for investigating processes that occur upon the annealing of frozen solutions in binary clathrate-forming low-boiling liquid-water systems allows us to propose a new method for preparing ultrafine medicinal substances by freeze-drying. This approach is of a universal nature and can easily be applied to virtually all of today’s low-dosage medicinal substances to improve their pharmacokinetic profiles and processibility.