Comparison of success rates of ‘transvaginal aspiration and tetracycline sclerotherapy’ versus ‘only aspiration’ in the management of non‐neoplastic ovarian cysts

Aim: To investigate the value of tetracycline sclerotherapy for management of recurrent or persisting nonneoplastic ovarian cysts in comparison to the aspiration without sclerotherapy. Material and Methods: Ninety-six patients with proven non-neoplastic ovarian cysts were randomized into two groups. Group 1 patients underwent cyst aspiration together with tetracycline sclerotherapy (n = 48). Group 2 patients underwent only cyst aspiration without tetracycline sclerotherapy (n = 48). Then, all patients were followed up monthly with ultrasonography for 12 months. The procedure was considered to have failed if the recurring cyst, detected by ultrasound, was 4 cm in size or greater. Results: There were no differences between the two groups regarding demographic data, initial cyst volume and tumor markers. Recurrence rates within 12 months were 14.6% in group 1 and 50% in group 2 (P < 0.001). Conclusion: Based on the recurrence rates, we suggest transvaginal aspiration together with tetracycline sclerotherapy rather than only simple transvaginal aspiration in the management of non-neoplastic ovarian cysts.