Mechanism of therapeutic effect of. cap alpha. /sub 2/-macroglobulin on the irradiated hemopoietic system

The mechanism of the action of macroglobulin in response to x irradiation of the hemopoietic system of rats was investigated. The synthesis of nucleic acids and total protein were determined at various stages of radiation sickness. Marked depression of protein and nucleic acid biosynthesis in the hemopoietic organs was found. Administration of macroglobulin led to normalization of DNA and RNA synthesis in bone marrow and lymphoid organs.