Haemodynamic and acid-base changes during laparoscopic and open cholecystectomy: an experimental study

SummaryThe aim of this study was to analyse and compare prospectively the haemodynamic and acid-base changes during laparoscopic and open cholecystectomy in experimental animals. Nineteen pigs were randomised to undergo either laparoscopic (group A, n = 10) or open (group B, n = 9) cholecystectomy. In group A, heart rate (HR), mean pulmonary arterial pressure (PAP), mean arterial pressure (MAP) and PCO2 levels, were statistically significantly increased (p < 0.05), while stroke volume (SV) and arterial pH were statistically significantly decreased (p < 0.01). In group B, these parameters did not vary significantly. In both groups, cardiac output (CO), central venous pressure (CVP), pulmonary arterial wedge pressure (PAWP) and total peripheral resistance (TPR) did not change significantly. In conclusion, these findings suggest that laparoscopic cholecystectomy might result in more cardiovascular and acid-base impairments than open cholecystectomy.