Profilin1 Sensitizes Pancreatic Cancer Cells to Irradiation by Inducing Apoptosis and Reducing Autophagy
2013
Pancreatic cancer has an extremely poor prognosis mainly due to lack of effective treatment
options. Radiotherapy is mostly applied to locally advanced cases, although tumor radioresistance limits the
effectiveness. Profilin1, a novel tumor suppressor gene, was reported to be down-regulated in various cancers
and associated with tumor progression. The objective of this study was to demonstrate how profilin1 affected
pancreatic cancer radiosensitivity. We showed profilin1 was down-regulated in pancreatic cancer cells after
exposure to radiation, and re-expression of profilin1 suppressed tumor cell viability and increased DNA
damage following irradiation. Further studies revealed that up-regulation of profilin1 facilitated apoptosis and
repressed autophagy induced by irradiation, which might sensitize pancreatic cancer cells to radiation
treatment. Our findings may provide a novel therapeutic strategy for sensitizing pancreatic cancer to
radiotherapy.
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