Нарушения липидного спектра в рамках метаболического синдрома на разных этапах формирования эссенциальной артериальной гипертензии в подростковом возрасте

The aim of this study was to assess dyslipidemia in teenagers with essential arterial hypertension (EAH) at different stages of the disease and its correlation with cardiovascular risk factors and arterial pressure (AP) daily profile. A total of 230 teenagers with EAH aged from 12 to 18 years (mean age of 14.9±2.0 years) were examined. All patients underwent 24 hour blood pressure monitoring. According to monitoring results, the following study groups were formed: group 1 comprised 68 patients with phenomenon of “white coat hypertension”; group 2 comprised 82 patients with labile arterial hypertension; group 3 comprised 80 patients with stable arterial hypertension. Control group included 27 healthy teenagers whose age and sex were similar to those in study groups. Blood lipids study was performed according to practical standards. To detect hyperlipidemias, the National Cholesterol Educational Program (NCEP peds) criteria revised in 1992 were used. Triglycerides (TC) level over 100 mg/dL (1.1 mmol/L) was criterion for hypertriglyceridemia in teenagers. Only teenagers with stable AH had clinically significant difference in the average values of TC and very low density lipoprotein cholesterol compared with control group adjusted for sex and age (р=0.027 and р=0.029 correspondingly). The covariance analysis showed that overweight, family history of hypertensive disease, smoking, and mean values of diastolic AP for all time intervals contribute to blood lipids disorders. Conclusions. Blood lipid disorders in teenagers with EAH can manifest at early stages of the disease and are the early markers of both metabolic syndrome and atherosclerosis requiring appropriate preventive measures.